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Thursday, June 15, 2023

Poverty and Ignorance

 

                                            

By Alec Helmke, PD4

I’m wrapping up week two in Uganda, and there are many updates to share! As I alluded to in my last post, I was fortunate to spend this last weekend on safari in Northwest Uganda. Along with several other US medical trainees, we left far too early in the morning on Friday for the long trek to Murchison National Park. My eyes struggled to stay open as we lurched over speed bumps along the Ugandan highways. Along the way, we stopped at the national rhino sanctuary, where we travelled with a guide to see the herds in their natural habitat. “A safe distance away” seemed a bit too close, and I certainly didn’t feel comforted when the guide pointed out how the rhino was sharpening its horn. I was more comforted to hear, however, that after local extinction in the 1980s, rhinos had been very successful following their reintroduction. Local conservationists were especially excited following the recent birth of a male rhino to a mother imported from the United States and a father from Kenya. They named him “Obama.”

That was only the first stop of many on a jam-packed and frequently tiresome journey. We arose early in the morning for game drives, during which our guide would point out the many unique animals I had previously only seen in zoos. Among the most thrilling sightings for us were giraffes, water buffalo, hippos, antelope, and even the elusive lions. Travelling in the safari vanwith the top open to ensure a panoramic view and to enjoy the fresh savannah breezeswas a surreal experience. As the sun set on our nighttime game drivesalthough I knew The Lion King is based on Tanzania and Kenya rather than UgandaI still couldn’t help playing “Circle of Life” over an over again in my head. But, to save you all the trouble of reading more (when we all know pictures are worth a thousand words), I’ll include some photos of the many animals we saw during our game drive experiences.

During the weekend, we spent some time on the Victoria Nile, which connects Lake Victoria to the Lake Albert delta. The watersheds from both lakes feed into the Nile River, which winds its way North into South Sudan, Sudan, and finally, Egypt. The first day we arrived, we viewed the waterfall for which Murchison Park is named. As the most powerful cataract in the world, Murchison Falls was an awe-inspiring sight, and the spray from the falls certainly felt nice to cool down in the Ugandan heat! We also viewed the falls from below. Moving upstream from the park in a barge, we saw many aquatic animals, including massive African alligators, before arriving at the base of the falls. We even got to enjoy a Nile on the Nile, that is, a Nile brand beer while floating on the river.


Although the game drives were undoubtedly beautiful, they took a serious toll on my sleep schedule. In fact, I had to laugh when the manager of our hotel described how beautiful the grounds of the property were. I knew that, leaving before sunrise and returning by sunset, I’d never get to see the hotel in daylight! We ended our trip with chimpanzee tracking in a nearby forest and sighted several of the agile climbers high up in the trees before hopping in the van to return to Kampala.

But I do work here too! This week has been spent shadowing pharmacists in the Infectious Disease Institute (IDI)an NGO located within Mulago that cares for patients with communicable diseases including HIV and TB. I met with John, a regulatory pharmacist, early in the week and learned from him the incredible effort that must go into study administration. Viewing a text of biblical proportions on his shelf, I asked him what it was for. He explained that the book consisted of protocols and regulatory documents for just one clinical trial. Although I have been able to gain limited experience with clinical research, it still astounded me that hundreds of pages of protocols were required to create a single 15-page study. I also learned that regulatory pharmacists are highly focused on education. In his role, John is tasked with imparting information to researchers and explaining the intricacies of study protocols to other healthcare professionals. It suits him well because John was actually a teacher before he started his pharmacy career.

On Tuesday and Wednesday, I joined Arnold in the IDI pharmacy. This pharmacy reminded me of the retail pharmacies you’d find in the United Statesexcept the drugs you encounter are a bit different. In the IDI pharmacy, they stock a variety of HIV and TB medications, along with a smattering of medicines used to treat other conditions. These medications are provided entirely free to IDI patients, which is critically important, as almost all medicines in Uganda are paid for out-of-pocket. Considering this, if medications were not offered for free, many patients simply wouldn’t be able to take them.

During my experience, Mike, another one of the pharmacists in the department, commented:

“The two biggest problems with healthcare in this country are poverty and ignorance,” he stated.

Mike’s comment struck me in its verisimilitude, not just for Uganda, but across the world. Here in Uganda, and throughout sub-Saharan Africa, infectious disease burden is remarkably high. HIV, TB, malaria, and diarrheal diseases kill millions each year. Poorer local governments frequently lack the financial resources to respond to these concerns with public health interventions such as widespread vaccine and prophylaxis distribution, parasite control, and sanitation. And many poorer patientshaving to purchase treatments and medical supplies out-of-pockettend to avoid care until it’s too late.

Yet, poverty isn’t limited to sub-Saharan Africa. The United Statesdespite possessing the largest GDP in the worldstill faces concerns of inequity. And for many of the conditions listed above, poor and marginalized patients are at high risk. For example, TB in the United States is particularly common among patients experiencing homelessness and among incarcerated individuals. Recent research even quantified poverty as the fourth most deadly disease in the United States.[i]

Mike continued to explain how ignorance can kill. He mentioned that millions of people in Uganda lack an understanding of the risks posed by infectious disease. Some individuals who receive mosquito nets choose to use these nets for fishing, failing to recognize that mosquito-borne malaria may lead to serious morbidity. Similarly, folks with HIV often fail to realize the risks of stopping treatment, even when they feel well. Particularly in Ugandawhere AIDS is so stigmatized as to be called by a different name (ISS)—patients may disregard their medications and appointments to avoid the shame of being recognized as HIV positive.

Again, ignorance isn’t a problem specific to Uganda. For many healthcare workers, what immediately comes to mind are vaccine skeptics, who fail to recognize the risks they face by choosing not to receive immunizations. I wonder ifgiven a chance to see the amount of detail that goes into clinical trial design like I saw with Johnthese folks would be less hesitant about vaccines. Another example pharmacists love to mention is antibiotic resistance. Like the HIV patients in Uganda, many patients with infections in the United States may stop taking antibiotics as soon as they feel better rather than continuing for the entire recommended course. In doing so, some particularly hardy germs may survive the medication’s onslaught and return later as drug-resistant bacteria. Our healthcare system is rapidly exhausting our supply of antibiotics to treat these superbugs, so patient education is crucial to keep us from running out for good.

Poverty and ignorance are the greatest healthcare challenges in sub-Saharan Africa, the United States, and across the globe. And I hope to use the tools I am learning here in Uganda to fight back against these killers. To address poverty, I will follow in IDI’s footsteps by making it my goal to expand patient access to vital, low-cost medications. And to address ignorance, like I mentioned in my last post, I must become an adept educator. Hopefully my fourth year will be great practice!

It’s hard to believe that the next week will already be my last. However, I’m excited to continue my learning next week in a new hospital, Kiruddu, where I will be rotating with several clinical pharmacists. Although there is so much more to shareincluding dancing alongside a traditional Ugandan troupe and an enlightening visit to an HIV prevention clinicI’ll sign off for now!

 



[i] Brady, D., Kohler, U., & Zheng, H. (2023). Novel Estimates of Mortality Associated With Poverty in the US. JAMA Internal Medicine, 183(6), 618-619.

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